Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation.
نویسندگان
چکیده
Differentiation and proliferation are usually considered to be antagonistic partners in development. However, in a recent issue of Science, Al Jord et al. (2017) show that key regulators of the mitotic cycle are redeployed in differentiating multiciliated cells to promote ciliogenesis without mitotic progression.
منابع مشابه
Allelopathy and Anti-mitotic Effects of Cuscuta campestris and Cuscuta monogyna Extracts on Plant Cell Division
Some natural compounds of plants including phenols and alkaloids induce mitosis depressive that are blocked cell division. Field dodder (Cuscuta campestris Yunck.) and eastern dodder (Cuscuta monogyna Vahl.) are the most widespread obligatory parasitic species. In the present study, end of summer 2015, field dodder and eastern dodder are collected from Alhagi maurorum Medik. host and Vine (Viti...
متن کاملPrevention of Acetaminophen-Induced Mitodepression with Myrobalan (Fruit of Terminalia chebula) in Allium cepa Model
Allium cepa bulbs were grown in pure tap water (group I), in seven concentrations of acetaminophen (7.81, 15.62, 31.25, 62.50, 125, 250, 500, and 1000 ppm) in the presence (group II) and absence of myrobalan (fruit of Terminalia chebula) at a fix concentration of 0.10 mg/mL. Parameters of study were mean root length, mitotic index, abnormal mitosis and chromosomal aberrations and morphology of ...
متن کاملPunctuated cyclin synthesis drives early embryonic cell cycle oscillations
Cyclin B activates cyclin-dependent kinase 1 (CDK1) at mitosis, but conflicting views have emerged on the dynamics of its synthesis during embryonic cycles, ranging from continuous translation to rapid synthesis during mitosis. Here we show that a CDK1-mediated negative-feedback loop attenuates cyclin production before mitosis. Cyclin B plateaus before peak CDK1 activation, and proteasome inhib...
متن کاملRadicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells.
Sam68 (Src-associated in mitosis 68 kDa) is a protein that associates with and is tyrosine phosphorylated by Src in a mitosis-specific manner, thereby raising the possibility of a role for Src in the regulation of the cell cycle. This study examines the effects of radicicol, a Src tyrosine kinase inhibitor, upon both the phosphorylation of Sam68 and mitotic progression in Src-transformed mouse ...
متن کاملA new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation.
Malignant cells are characterized by abnormal segregation of chromosomes during mitosis ("aneuploidy"), generally considered a result of malignancy originating in genetic mutations. However, recent evidence supports a century-old concept that maldistribution of chromosomes (and resultant genomic instability) due to abnormalities in mitosis itself is the primary cause of malignancy rather than a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Developmental cell
دوره 43 4 شماره
صفحات -
تاریخ انتشار 2017